Anticancer Plant Secondary Metabolites Induce Linker Histone Depletion from Chromatin
Background: Many plant secondary metabolites click here (PSMs) were shown to intercalate into DNA helix or interact with DNA grooves.This may influence histone-DNA interactions changeing chromatin structure and genome functioning.Methods: Nucleosome stability and linker histone H1.2, H1.4 and H1.5 localizations were studied in HeLa cells after the